DNA/RNA Synthesis

Oligo Modifications

Our on-going R&D programs allow us to continuously increase our range of products.
The followingcontains information on some of the common modifications offered by 1st BASE.
Please enquire for other modifications or chemistries not listed.

 

Modification Chemistry Applications
Attachment Chemistry Chemical groups for mobilization of oligos to solid support/surfaces.
  • Amino linkers
  • Thiol linkers
Labeling and Detection Chemistry Addition of chemical groups for colorimetric or fluorescence detection.
  • Fluorophores
  • Biotinylation
  • Amino linkers
Quantitative Analysis
  • qPCR
  • Fluorophores
  • Dark quenchers
Anti-sense Technology Inhibitors to gene expression for knockdown studies in functional genomics
  • RNAi and siRNA
  • PTO backbone modification
  • 2'-O-Me RNA
Extension Blockers and Spacers
  • Phosphorylation
  • Spacers
  • Dideoxy nucleotides
Wobbles
  • Degenerate Base Oligos
  • Inosine